Can you give propofol with egg allergy?

The bottom line: Patients with soy allergy or egg allergy can receive propofol without any special precautions. Any patient, whether soy or egg-allergic or not, who has an apparent allergic reaction to propofol should be evaluated by an allergist.

What allergy is a contraindication for propofol?

Propofol (2,6-diisopropylphenol) is a commonly used intravenous drug for induction and maintenance of anesthesia during endoscopic procedures. The drug, though generally considered safe, has been considered a relative contraindication in egg and soy allergic patients.

When is propofol contraindicated?

Propofol is contraindicated for use when general anesthesia or sedation is contraindicated. Propofol is also contraindicated in patients with hypersensitivity to the drug or to any of the components.

What are allergic reactions to propofol?

Tell your doctor right away if you start to have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth, or throat after receiving this medicine.

Why is propofol contraindicated in egg allergy?

Background: Propofol is thought to be a potential cause of allergic reactions in patients allergic to egg, soy or peanut, since current formulations contain an emulsion that includes egg lecithin and soybean oil.

What can you use instead of propofol?

Fospropofol (Lusedra®) is a water-soluble, non-pyrogenic, iso-osmotic pro-drug sedative-hypnotic agent that is metabolized to propofol, and, if dosed appropriately, may be an alternate drug selection to propofol in some patients undergoing monitored anesthesia care (MAC).

Is propofol safe for food allergy patients a review of the evidence?

The current published evidence does not elucidate that propofol allergy and food allergies are linked directly, but this drug should be used with caution in atopic patients with allergies to egg and/or soya bean oil.

What is the 1 2 life of propofol?

Half-life: Propofol is bi-phasic, with its initial half-life being relatively quick, around 40 minutes, and its terminal half-life usually being 4 to 7 hours. Context-sensitive half-time may be up to 1 to 3 days after a 10-day infusion.

How long does it take for propofol to get out of your system?

The half-life of elimination of propofol has been estimated to be between 2 and 24 hours. However, its duration of clinical effect is much shorter, because propofol is rapidly distributed into peripheral tissues. When used for IV sedation, a single dose of propofol typically wears off within minutes.

Do eggs have lecithin?

The phospholipid, or lecithin, found in egg markedly inhibits the cholesterol absorption. Egg contains a higher quality protein than protein found in meat, milk or fish.

Is propofol better than versed?

We conclude that propofol is a sedative agent with the same safety, higher clinical effectiveness, and a better cost-benefit ratio than midazolam in the continuous sedation of critically ill patients.

Can you take propofol if you have an egg allergy?

Of these, 201 (66%) had an egg allergy, 226 (74%) had a peanut allergy, 28 (9%) had a soybean allergy and 12 (4%) had a legume allergy. These were compared with 892 allergy-free patients who were exposed to propofol. In 10 (3%) allergy patients and 124 (14%) allergy-free patients, criteria for a possible allergic reaction were met.

How many children are on propofol for peanut allergy?

We identified 304 food-allergic children and 649 procedures where propofol was administered. Of these, 201 (66%) had an egg allergy, 226 (74%) had a peanut allergy, 28 (9%) had a soybean allergy and 12 (4%) had a legume allergy.

Are there any signs of allergy to propofol?

In study B we found no signs of allergic reactions towards propofol in 171 retrieved anaesthetic charts from 99 patients with specific IgE to egg, soy or peanut. Conclusion: No connection between allergy to propofol and allergy to egg, soy or peanut was found.

Are there any contraindications to the use of propofol?

No evidence for contraindications to the use of propofol in adults allergic to egg, soy or peanut† No connection between allergy to propofol and allergy to egg, soy or peanut was found. The present practice of choosing alternatives to propofol in patients with this kind of food allergy is not evidence based and should be reconsidered.