Can you overdose ANTISEDAN?

Signs of overdose were dose-related and consistent with those expected in non-sedated dogs having received a stimulant. Signs seen at elevated doses included excitement, panting, trembling, vomiting, soft or liquid feces or vasodilation (injection) of the sclera.

What happens if you give ANTISEDAN sq?

Occasional vomiting may occur with ANTISEDAN use. Rarely, a brief state of excitement or apprehensiveness may be seen in ANTISEDAN-treated dogs. Other potential side effects of α2-antagonists, such as ANTISEDAN, include hypersalivation, diarrhea, and tremors.

What happens if you give ANTISEDAN IV?

Atipamezole administered IV may result in rapid relaxation of vascular tone, which coupled with bradycardia could result in cardiovascular collapse.

Is ANTISEDAN safe for cats?

IMPORTANT SAFETY INFORMATION: Do not use DEXDOMITOR in dogs or cats, and ANTISEDAN in dogs, with cardiovascular disease, respiratory disorders, liver or kidney diseases, or in conditions of shock, severe debilitation, or stress due to extreme heat, cold or fatigue.

Why is atipamezole not used in humans?

Atipamezole Use in Humans It should be noted that atipamezole is currently not available for use in humans, internationally. In comparison with veterinary species, the human is more sensitive on a mg/kg basis to the α-2 agonist effects of dexmedetomidine and presumably to its close relative, medetomidine.

What is the reversal agent for Xylazine?

Tolazine is the antidote for xylazine and is administered to reverse affects. Essential for completing surgical procedure. Xylazine provides heavy sedation but can also produce bloat in ruminants.

How long does it take for Dexdomitor to wear off?

Sedation lasts for at least 120 minutes post administration and analgesia lasts for at least 90 minutes. Spontaneous recovery occurs within 3 hours.

Is Antisedan used in humans?

Atipamezole (Antisedan®) is an α-2 adrenergic antagonist labeled for use as a reversal agent for the sedative medetomidine. It has been used successfully in the treatment of amitraz toxicosis to reverse CNS depression, bradycardia, GI stasis and hyperglycemia (Grossman, 1993; Gwaltney-Brant, 2004).

Is atipamezole used in humans?

In humans, atipamezole at doses up to 30 mg/subject produced no cardiovascular or subjective side effects, while at a high dose (100 mg/subject) it produced subjective symptoms, such as motor restlessness, and an increase in blood pressure.

What are the side effects of precedex?

Common side effects of Precedex include:

• low or high blood pressure (hypotension or hypertension),
• slow heart rate (bradycardia),
• nausea,
• dry mouth,
• irregular heartbeat,
• fever,
• vomiting,
• low blood plasma,

Can you reverse precedex?

Amitraz works by the same mechanism as dexmedetomidine and is thus easily reversed by atipamezole. Atipamezole also reverses the hypotension caused by tizanidine (a muscle relaxant) toxicity, and relieves toxicity from decongestants such as ephedrine and pseudoephedrine.

Which is the correct chemical formula for Antisedan?

ANTISEDAN (atipamezole hydrochloride) is a synthetic α 2 -adrenergic antagonist. The chemical name is 4- (2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride. The molecular formula is C 14 H 16 N 2 •HCl and structural formula is:

How is Antisedan used to treat sedation and analgesia?

ANTISEDAN is administered intramuscularly (IM) for reversal of sedation and analgesia regardless of the route used for DEXDOMITOR or DOMITOR. The atipamezole dose for the reversal of IV DEXDOMITOR or DOMITOR is 3750 mcg/m 2. The atipamezole dose for the reversal of IM DEXDOMITOR or DOMITOR is 5000 mcg/m 2 .

What are the side effects of Antisedan for animals?

Animals should be monitored closely for persistent hypothermia, bradycardia, and depressed respiration, until signs of recovery persist. 3. Analgesia reversal: Atipamezole reverses analgesic effects as well as sedative effects. Additional procedures for the control of pain may be required.

What is the dose of Antisedan for reversal of Dexdomitor?

ANTISEDAN is administered intramuscularly (IM) for reversal of sedation and analgesia regardless of the route used for DEXDOMITOR or DOMITOR. The atipamezole dose for the reversal of IV DEXDOMITOR or DOMITOR is 3750 mcg/m 2.