Does ADP induced platelet aggregation?

ADP not only causes primary aggregation of platelets but is also responsible for the secondary aggregation induced by ADP and other agonists. ADP also induces platelet shape change, secretion from storage granules, influx and intracellular mobilization of Ca2+, and inhibition of stimulated adenylyl cyclase activity.

How does ADP cause platelet aggregation?

Acting through cell surface receptors, ADP activates platelets resulting in shape change, aggregation, thromboxane A2 production, and release of granule contents.

Why do platelets secrete ADP?

Although it is itself a weak agonist, ADP plays a key role in platelet function because when it is secreted from its storage pool in platelet dense granules, it amplifies the platelet responses induced by other platelet agonists9,11 and stabilizes platelet aggregates.

Does ATP inhibit platelet aggregation?

Extracellular adenosine triphosphate (ATP) regulates platelet reactivity by way of direct action on platelet purinergic receptors or by hydrolysis to adenosine diphosphate (ADP). Subsequent metabolism of ATP and ADP to adenosine monophosphate (AMP) and adenosine inhibits platelet aggregation.

How is platelet aggregation measured?

A platelet aggregation test requires a blood sample. The sample is initially examined to see how the platelets are distributed through the plasma, the liquid part of the blood. A chemical is then added to your blood sample to test how quickly your platelets clot.

What is the meaning of platelet aggregation?

Definition. The platelet aggregation blood test checks how well platelets , a part of blood, clump together and cause blood to clot.

Does ATP activate platelets?

ATP, in turn, can initiate platelet activation through the P2X1 receptor and inhibit ADP-mediated activation when acting as an antagonist on the P2Y receptors (Cattaneo, 2007).

What is platelet aggregation test used for?

The platelet aggregation blood test checks how well platelets, a part of blood, clump together and cause blood to clot.

Is platelet aggregation a good thing?

Platelet aggregation, the process by which platelets adhere to each other at sites of vascular injury, has long been recognized as critical for hemostatic plug formation and thrombosis.

What happens during platelet aggregation?

Platelet aggregation and thrombosis are the key phenomena in atherosclerosis and CVD. Platelets stick to the damaged vessel wall to form a plaque, and then stick to each other (aggregate) and release adenosine diphosphate (ADP) and thromboxane A2 (TXA2), which promote further aggregation.