Does HCTZ worsen renal function?

Hydrochlorothiazide can aggravate kidney dysfunction and is used with caution in patients with kidney disease. Hydrochlorothiazide can lower blood potassium, sodium, and magnesium levels.

Can hydrochlorothiazide cause kidney failure?

If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure.

Why thiazides are contraindicated in renal failure?

It is generally thought that thiazides are ineffective in patients with more advanced CKD because of more proximal sodium reabsorption in the nephron. This results in less sodium being delivered to the distal tubule and therefore less thiazide diuretic action in the distal tubule.

Can HCTZ cause decreased GFR?

(Loop diuretics are preferred when creatine clearance is less than 40 to 50 mL/min.) In fact, hydrochlorothiazide decreases GFR without altering renal blood flow.

Is Triamterene hard on the kidneys?

This medicine may cause serious kidney problems, including kidney stones.

Does diuretics increase creatinine?

Observational studies with small sample size and short duration have shown that diuretics decrease blood pressure (BP) and improve edema in CKD patients but their use, particularly at higher doses, is associated with rise in serum creatinine and several metabolic complications [4,8–9].

Does HCTZ affect creatinine levels?

Hydrochlorothiazide (HCTZ) is a diuretic and may cause a slight elevation in the serum creatinine as your blood pressure falls.

Is HCTZ a strong diuretic?

Microzide (hydrochlorothiazide (HCTZ)) is a well-tolerated water pill that’s often the first-choice treatment for mild high blood pressure. A strong diuretic (water pill) that works well to get rid of extra fluids in your body through urination. Lowers your blood pressure and your risk of heart attack and stroke.