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How effective is PCV chemotherapy?

How effective is PCV chemotherapy?

Six-month survival after the start of PCV chemotherapy for the entire group was 68%, 1-year survival was 18%, and 2-year survival was 5%. Progression-free survival at 6 months (APF6) was 29%. No difference in response was found in patients treated with intensified or standard PCV.

What is the survival rate for oligodendroglioma?

Oligodendroglioma Prognosis The relative 5-year survival rate for oligodendroglioma is 74.1% but know that many factors can affect prognosis. This includes the tumor grade and type, traits of the cancer, the person’s age and health when diagnosed, and how they respond to treatment.

How is PCV chemo administered?

The regimen is complex – three agents administered over a period of 6 [10,13] to 8 [2,3,12] weeks depending on the intensity. For example, a typical regimen of PCV consists of CCNU at 110 mg/m2 on day 1 followed by procarbazine at 60 mg/m2/day on days 8–21, all oral and at home.

How long can you live with oligodendroglioma?

About 30 to 38% of people with this type of tumour will survive for 5 years or more after they are diagnosed. Read more about oligodendroglioma brain tumour types and treatments.

What are the side effects of PCV?


  • Reactions where the shot was given. Redness. Swelling. Pain or tenderness.
  • Fever.
  • Loss of appetite.
  • Fussiness (irritability)
  • Feeling tired.
  • Headache.
  • Chills.

Does PCV cause hair loss?

Your hair will get thinner. Or you may lose all the hair from your head. You may also lose your eyelashes and eyebrows, as well as other body hair. Hair loss usually starts after your first or second treatment.

Can oligodendroglioma grade 2 Be Cured?

Oligodendroglioma, a rare tumor that starts in the brain or spinal cord, has no cure. Catching the cancer early and starting treatment is the best way to prolong life — people with stage II of this kind of cancer live an average of 12 years after diagnosis.

Does oligodendroglioma have a cure?

Factors that can affect prognosis include the tumor’s location and grade, and your age and health. Doctors can successfully treat many cases of oligodendroglioma. Sometimes people need more than one surgery to remove the whole tumor and ensure it does not return.

Why PCV test is done?

Also known as the haematocrit test, the PCV or Packed Cell Volume Test is a test done to diagnose polycythaemia, dehydration or anaemia in certain patients. It is generally a part of the full blood count test that is used to estimate the need for certain blood transfusions and monitor the response to treatment.

Is there a cure for oligodendroglioma?

How many years is a pneumonia shot good for?

65 years old or older: two shots, which will last you the rest of your life. Between 2 and 64 years old: between one and three shots if you have certain immune system disorders or if you’re a smoker.

Which is better for oligodendrogliomas PCV or TMZ?

We state that TMZ chemotherapy, rather than PCV chemotherapy, in combination with RT is a reasonable treatment option for patients with newly diagnosed oligodendrogliomas.

Which is the best chemotherapy for oligodendroglioma?

Patients with newly diagnosed oligodendroglioma have a median OS of more than 10 years after treatment with the combination of chemotherapy and RT, regardless of tumor grade. The optimal chemotherapy regimen for patients with newly diagnosed oligodendroglioma, however, remains controversial.

Are there clinical trials for co-deletion 1p / 19q?

Two phase III clinical trials (RTOG 9402 and EORTC 26951) proved favorable effects of radiotherapy (RT) with chemotherapy (procarbazine, lomustine and vincristine; PCV) in patients with AO carrying chromosomal mutation of co-deletion1p/19q even if it was not the primary endpoint of these studies.

Which is better for cancer, PCV or temozolomide?

While the most direct evidence comes from clinical trials that utilized PCV, a chemotherapy regimen consisting of procarbazine, CCNU (lomustine), and vincristine, there is circumstantial evidence suggesting that the oral agent temozolomide (TMZ), which is both better tolerated and logistically simpler than PCV, may also be effective.