How long does it take evicel to thaw?

How long does it take evicel to thaw?

Thaw the two components of EVICEL® (BAC2 and Thrombin) in one of the following ways: 2°C to 8°C (refrigerator): vials thaw within 1 day; or. 20°C to 25°C (room temperature): vials thaw within 1 hour; or.

What is evicel used for?

Evicel is a medicine that is used as a sealant (glue). It is available as two solutions, one containing the active substance human clottable protein (50 to 90 mg/ml), and the other containing the active substance human thrombin (800 to 1200 international units per millilitre).

Is evicel human tissue?

EVICEL® is a human plasma-derived fibrin sealant. EVICEL® is supplied as a package containing two separate vials (glass type I) with rubber stoppers (type I), each containing 2 ml or 5 ml clear or slightly opalescent solution of Fibrinogen and Thrombin (Human), respectively.

How do fibrin sealants work?

Fibrin sealant is a two-component material consisting of fibrinogen and thrombin. In the presence of small amounts of calcium and factor XIII, the thrombin converts fibrinogen into insoluble fibrin, the final stable form of the agent. Fibrin sealant now has over a century of development and use.

How do you thaw evicel?


  1. 2°C to 8°C (refrigerator): vials thaw within 1 day; or.
  2. 20°C to 25°C (room temperature): vials thaw within 1 hour; or.
  3. 37°C (warm water bath): vials thaw within 10 minutes and must not be left at this temperature for longer than 10 minutes. The temperature must not exceed 37°C.

How long is Vistaseal good for?

The dual applicator mixes the fibrinogen and thrombin as the plunger is depressed. It is shipped and stored frozen, and has a shelf life of up to 2 years. VISTASEAL typically requires 5 minutes of thawing time in a sterile water bath (37°C) and is then ready for immediate use.

How do I use evicel?

Apply EVICEL® to the surface of bleeding tissue only. Do not inject directly into the circulatory system or into tissues. If the hemostatic effect is not complete, apply a second layer. The amount of EVICEL® required depends upon the area of tissue to be treated and the method of application.

What is tisseel glue?

Tisseel Fibrin Sealant (fibrinogen human, human thrombin kit) is a fibrin sealant used as an adjunct to hemostasis in adult and pediatric patients (older than 1 month of age) undergoing surgery when control of bleeding by conventional surgical techniques (such as suture, ligature, and cautery) is ineffective or …

What is thrombin made of?

Thrombin is composed of two polypeptide chains of 36 (A chain) and 259 (B chain) residues that are covalently linked through a disulfide bond between residues C1 and C122 (Figure 4) (Bode et al. 1992; Bode 2006).

Is FloSeal a fibrin sealant?

into 3 groups: a control group, a matrix hemo- static sealant (FloSeal) group, and a 2-component fibrin sealant (Tisseel) group.

What is fibrin sealant made of?

Human Fibrin Glue (HFG) is made of two components contained in separate vials: a freeze dried concentrate of clotting proteins, mainly fibrinogen, Factor XIII and fibronectin (the sealant) and freeze dried thrombin (the catalyst).

How do I defrost Vistaseal?

Place the blister containing the VISTASEAL Dual Applicator at room temperature until the VISTASEAL Fibrin Sealant (Human) is ready to use. After thawing, it is not necessary to warm the product for its use. After thawing, the solutions must be clear to slightly opalescent and colorless to pale yellow.