What do I give cisplatin with?

What do I give cisplatin with?

Hydration is recommended to induce diuresis and reduce the concentration of cisplatin in the kidneys. Isotonic saline (0.9% sodium chloride) is recommended for hydration fluids, and many centers also include potassium and magnesium in these hydration fluids due to the risk of electrolyte wasting.

What is cisplatin for?

Cisplatin, a chemotherapy drug, is best known for curing testicular cancer. It is also used in the treatment of a wide range of other cancers, including lung, bladder, cervical, and ovarian cancers. Cisplatin and other similar platinum-based drugs were developed with National Cancer Institute (NCI) support.

Why is dexamethasone given with cisplatin?

Glucocorticoids (GCs) such as dexamethasone (DEX) are widely used as a co-treatment with chemotherapy because of their effectiveness to prevent edema, nausea, and toxic reaction caused by cytotoxic treatment in tumor patients [1]. GCs co-treatment also improves appetite, weight loss and relieves bone pain [2].

How many cycles of cisplatin can you have?

You usually have between 4 to 6 cycles of treatment taking from 3 to 6 months. You have gemcitabine as a drip into your bloodstream over 30 minutes. You have cisplatin as a drip into your bloodstream over 1 to 4 hours.

Is cisplatin a strong chemo?

Cisplatin is a potent chemotherapeutic drug that has shown efficacy for the treatment of many malignancies including head and neck, ovarian, sarcomas, lymphoma, and prostate cancer.

What is the most common side effect of cisplatin?

The following side effects are common (occurring in greater than 30%) for patients taking Cisplatin: Nausea and vomiting. Nausea may last up to 1 week after therapy. Anti-nausea medication is given before the infusion, and a prescription is also given for use after.

Will I lose my hair with cisplatin?

v Hair loss is minimal with cisplatin, but some patients do experience more hair loss than others. Hair growth should return upon completion of treatment.

How bad is cisplatin?

Cisplatin may cause serious kidney problems. Tell you doctor right away if you have blood in urine, change in frequency of urination or amount of urine, difficulty in breathing, drowsiness, increased thirst, loss of appetite, nausea or vomiting, swelling of the feet or lower legs, or weakness.

Do you lose your hair on cisplatin?

v Hair loss is minimal with cisplatin, but some patients do experience more hair loss than others. Hair growth should return upon completion of treatment. v Nausea and vomiting are not unusual but are less common today than in the past because of much improved anti-nausea medications.

Are there any clinical trials for cisplatin plus?

The initial study 5 by the Eastern Cooperative Oncology Group (ECOG) utilized the recommended single-agent dose and schedule of 250 mg/m 2 by 24-hour infusion administered every 3 weeks. This phase II study of 34 patients demonstrated a 40% RR with a median survival of 9.2 months and a 1-year survival of 32%.

Are there any side effects to cisplatin plus gemcitabine?

In clinical studies, the most commonly reported gemcitabine plus cisplatin side effects are shown here: On average, 13% of patients discontinue gem/cis treatment due to unacceptable side effects. How often is monitoring needed?

What are the end points of cisplatin plus Fu?

The goal of this trial was to compare the efficacy and toxicity of the two regimens, cisplatin plus FU (CF) and cisplatin plus paclitaxel (CP). The primary end point was overall survival at 1 year. Secondary end points included response and toxicity.

Which is better cisplatin or gemcitabine for NSCLC?

Cisplatin plus gemcitabine is a standard regimen for first-line treatment of advanced non–small-cell lung cancer (NSCLC). Phase II studies of pemetrexed plus platinum compounds have also shown activity in this setting.