What does a positive anti-cardiolipin IgG mean?
What does a positive anti-cardiolipin IgG mean?
Anti-cardiolipin autoantibodies can be any combination of IgG, IgM and IgA classes. IgG antibodies are the most prevalent class of autoantibody and the class with the greatest clinical correlation. Samples found to high levels of IgG anti-cardiolipin are the most likely to display overt clinical symptoms.
What is cardiolipin AB IgA IgG IgM?
The cardiolipin antibodies blood test, IgA, IgG, and IgM is used to help investigate inappropriate blood clot formation, to help determine the cause of recurrent miscarriage, or as part of an evaluation for antiphospholipid syndrome or sometimes other autoimmune diseases.
What does high cardiolipin AB IgM mean?
The levels of these antibodies are often high in people with abnormal blood clotting, autoimmune diseases like systemic lupus erythematosus (SLE), or repeated miscarriages.
What is anti-cardiolipin antibody IgM?
Cardiolipin antibodies are the most common antiphospholipid antibody, a group of autoantibodies associated with excessive clotting and autoimmune diseases, such as lupus. They are frequently detected with other antiphospholipid antibodies, such as lupus anticoagulant and anti-beta-2 glycoprotein 1.
What is normal anticardiolipin antibody?
Anticardiolipin Antibody (IgG, IgM, IgA)
| General Information | |
|---|---|
| Normal Range | < 20 CU for IgG, IgM and IgA |
| Reflexive Testing | None |
| Associated Testing | Antiphospholipid Syndrome Criteria Panel, Lupus Anticoagulant Screen |
| Special Instructions & Forms |
Can cardiolipin antibodies go away?
The antibodies often fade away when the cancer is treated. The 2 most common types of antiphospholipid antibodies are lupus anticoagulant and anticardiolipin antibodies. Testing for lupus anticoagulant often uses a test such as the Russell viper venom time (RVVT) or kaolin clotting time.
Why is my IgM high?
IgM. High levels of IgM can mean macroglobulinemia, early viral hepatitis, mononucleosis, rheumatoid arthritis, kidney damage (nephrotic syndrome), or a parasite infection is present.
How is anticardiolipin antibodies treated?
Your treatment plan Most people with APS need to take anticoagulant or antiplatelet medication daily for the rest of their life. If blood tests show you have abnormal antiphospholipid antibodies, but you don’t have a history of blood clots, low-dose aspirin tablets are usually recommended.
Is High IgM serious?
Hyper IgM syndromes are caused by very rare, one-in-a-million, and potentially life-threatening genetic mutations that severely compromise the immune system and resulting in the individual’s inability to produce antibodies. Patients with hyper IgM are at significant risk for opportunistic and repeated infections.
Does IgG mean active infection?
When IgG antibodies are present it, often indicates a past infection but does not exclude recently infected patients who are still contagious, especially if detected with IgM antibodies.
What happens if IgM is high?
High levels of IgM can mean macroglobulinemia, early viral hepatitis, mononucleosis, rheumatoid arthritis, kidney damage (nephrotic syndrome), or a parasite infection is present.