What is Bioisosterism explain with example?

From Wikipedia, the free encyclopedia. In medicinal chemistry, bioisosteres are chemical substituents or groups with similar physical or chemical properties which produce broadly similar biological properties to another chemical compound.

What is a classical isostere?

Classical Isosteres are molecules or ions with similar shape and often electronic properties. Many definitions are available. but the term is usually employed in the context of bioactivity and drug development. Such biologically-active compounds containing an isostere is called a bioisostere.

What are Isosteres with example?

Isosteres are atoms, molecules, or ions of similar size containing the same number of atoms and valence electrons. Example 1. Consider neon, the noble gas at the end of the second row of the periodic table.

What is ring equivalent bioisosteres?

Bioisosteres – A bioisostere is a molecule resulting from the exchange of an atom or of a group of atoms with an alternative, broadly similar, atom or group of atoms.

What is physicochemical properties of drugs?

Physicochemical Properties of Drug. DEFINITION: The ability of a chemical compound to elicit a pharmacological/ therapeutic effect is related to the influence of various physical and chemical (physicochemical) properties of the chemical substance on the bio molecule that it interacts with.

What is a type of bioisosterism?

Bioisosteres are classified into the following two types: Classical bioisosteres. Nonclassical bioisosteres.

How do you identify bioisosteres?

Application of Molecular Fields to Bioisostere Finding The principle behind fragment replacement methods to identify bioisosteres is simple: remove a portion of an active molecule, search a fragment database for a replacement moiety that will physically fit into the vacated space, and score the replacement for …

WHO classified and subdivided bioisosteres into two broad categories?

CLASSIFICATION OF BIOISOSTERISM 4:12 In 1970, Burger classified and subdivided bioisosteres into two broad categories according to the degree of electronic and steric factors. 2.1. Classic isosteres: 2.1. A.

What is the difference between Isosteres and Bioisosteres?

Friedman (1951): Bioisosteres are atoms or molecules that fit the broadest definition for isosteres and have the same type of biological activity. Thornber (1979): Groups or molecules which have chemical and physical similarities producing broadly similar biological effects.

What is meant by isostructural?

: relating to or having a similar crystal structure in that the atoms correspond in position and function although there may not be close chemical relationship : isotypic —used of minerals and other crystalline substances calcite and sodium nitrate are isostructural — compare isomorphous.

What is the difference between Isosteres and bioisosteres?

What are the 4 chemical properties?

Examples of chemical properties include flammability, toxicity, acidity, reactivity (many types), and heat of combustion.

What is the meaning of the word pyridone?

Wiktionary(0.00 / 0 votes)Rate this definition: pyridone(Noun) Either of two isomeric derivatives of pyridine having a carbonyl group either ortho- or para- to the nitrogen atom; the pyridine analogue of quinone.

What do you mean by bioisostere in Wikipedia?

Bioisostere. From Wikipedia, the free encyclopedia. Jump to navigation Jump to search. bioisosteres are the groups which can get substituted to enhance the activity of drug. In medicinal chemistry, bioisosteres are chemical substituents or groups with similar physical or chemical properties which produce broadly similar biological properties

How are pyridones and azinones react with nitrogen?

Pyridones and azinones are weak acids of pKa ca. 11 (see Section 3.2.1.3.4.4 ). They form mesomeric anions (cf. 140 → 373) that react very readily with electrophilic reagents at the nitrogen, oxygen, or carbon atom, depending on the circumstances (see Section 3.2.3.7.2 ).

Which is a classical bioisostere procaine or procainamide?

Classical bioisosteres. Procainamide, an amide, has a longer duration of action than Procaine, an ester, because of the isosteric replacement of the ester oxygen with a nitrogen atom. Procainamide is a classical bioisostere because the valence electron structure of a disubstituted oxygen atom is the same as a trisubstituted nitrogen atom,…