What is CD45 a marker for?

CD45 is used as a marker of all hematopoietic cells (blood cells), except for mature erythrocytes (red blood cells) and platelets.

What cells are CD45 +?

CD45 antigen (leukocyte common antigen), a unique and ubiquitous membrane glycoprotein with a molecular mass of about 200 kDa, is expressed on almost all hematopoietic cells except for mature erythrocytes.

What is the difference between CD45 and CD45R?

CD45 also known as B220, Ly-5 and T200 is a member of the protein tyrosine phosphatase (PTP) family with a molecular weight of approximately 220 kDa. There are many different isotypes of CD45 family, with CD45R being the longest protein and with more glycosylation when expressed on B cell.

Are histiocytes CD45 positive?

Histiocytes and granulocytes mainly express the B and O. CD45 proteins that do not comprise all of the isoforms are designated CD45R (=restricted). CD45 is detected in the large majority of haematolymphoid neoplasms, i.e., leukaemias and malignant lymphomas. Overall, about 90% of malignant lymphomas are CD45 positive.

Are plasma cells CD45+?

The mean bone marrow plasma cell content by flow cytometry was 22% (median, 14%; range, 0.2–91%). In all, 30% of plasma cells expressed CD45 by flow cytometry (median, 14%; range, 0.1–100%). Among all patients, 44% (33/75) had more than 20% of plasma cells expressing CD45 and were categorized as the CD45+ group.

Are plasma cells positive for CD45?

Monoclonal Gammopathy and Its Detection Normal peripheral blood plasma cells are CD45+. In bone marrow, there are two subsets of plasma cells: one major subset positive for CD45 and a smaller negative one. Aberrant CD56 expression is identified in most patients with myeloma.

Does everyone have CD45 cells?

CD45 was initially characterized as a leukocyte common antigen and can be found on all hematopoietic cells with exception of platelets and red blood cells. It is a key regulator of antigen-mediated signaling and activation in B- and T lymphocytes.

Do all immune cells express CD45?

CD45 is a major transmembrane glycoprotein expressed on all nucleated hematopoietic cells. Eight isoforms of CD45 are distributed through the immune system according to cell type and degree of cellular differentiation.

Is plasma cell leukemia the same as multiple myeloma?

Plasma cell leukemia is clinically and genetically distinct from multiple myeloma.

What is the normal range for plasma cells?

Normal range: 0.57-2.63 mg/dL Multiple myeloma or another plasma cell disorder may be indicated by increased lambda free light chains and a decreased kappa/ lambda ratio.