What is N-myc gene?

N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene.

What is MYCN amplification neuroblastoma?

Neuroblastoma (NB) is a remarkably heterogenic childhood tumor of the sympathetic nervous system with clinical behavior ranging from spontaneous regression to poorly differentiated tumors and metastasis. MYCN is amplified in 20% of cases and correlates with an undifferentiated, aggressive phenotype and poor prognosis.

What chromosome is N-myc on?

The N-myc gene, MYCN, is located on the distal short arm of chromosome 2 (2p24). In cells with amplification, the extra copies typically reside as double minute or homogenously staining region amplicons (77). Additional genes may be coamplified with MYCN in a subset of neuroblastomas (DDX1, NAG, and ALK; ref.

What is the function of MYC?

c-Myc is a multifunctional transcription factor which drives the multiple synthetic functions necessary for rapid cell division while at the same time inhibiting expression of genes with antiproliferative functions. Because of its propensity to induce apoptosis, its expression is tightly regulated.

What is the difference between MYC and MYCN?

Expression of MYCN is tissue specific, and is found during early developmental stages, whereas expression of MYC is more generalized (Fig. 1C). For example, expression of MYCN is highest in forebrain, kidney, and hindbrain of newborn mice, and is virtually absent in all tissues of adult mice.

What does Mycn stand for?

MYCN (MYCN Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene.

What kind of protein is the N-myc gene?

N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene .

Where is the MYCN gene located in the cell?

The MYCN gene is a member of the MYC family of transcription factors and encodes a protein with a basic helix-loop-helix ( bHLH) domain. This protein is located in the cell nucleus and must dimerize with another bHLH protein in order to bind DNA.

How are N-Myc and MYCNOS related?

N-Myc and MYCNOS are co-regulated both in normal development and in tumor cells, so it is possible that the two transcripts are functionally related. It has been shown that the antisense RNA encodes for a protein, named NCYM, that has originated de novo and is specific to human and chimpanzee.

What is the function of NCYM in MYCN?

“NCYM, a Cis-antisense gene of MYCN, encodes a de novo evolved protein that inhibits GSK3beta resulting in the stabilization of MYCN in human neuroblastomas.” Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH NCYM, PHOSPHORYLATION.