What is PEG used for?
What is PEG used for?
Polyethylene glycol 3350 is used to treat occasional constipation. Polyethylene glycol 3350 is in a class of medications called osmotic laxatives. It works by causing water to be retained with the stool. This increases the number of bowel movements and softens the stool so it is easier to pass.
Why is PEG used in drug delivery?
Polyethylene glycol (PEG) is widely utilized in drug delivery and nanotechnology due to its reported “stealth” properties and biocompatibility. It is generally thought that PEGylation allows particulate delivery systems and biomaterials to evade the immune system and thereby prolong circulation lifetimes.
What drugs is PEG found in?
Polyethylene glycol, referred to as PEG, is used as an inactive ingredient in the pharmaceutical industry as a solvent, plasticizer, surfactant, ointments, and suppository base, and tablet and capsule lubricant.
How does PEG evade immune system?
Poly(ethylene glycol) (PEG) helps nanomaterials evade the immune system by modifying the composition of proteins that are adsorbed on the surface of the materials. To support your research needs, Advanced BioChemicals offers various PEG derivatives to meet your project requirements.
Is propylene glycol harmful to the human body?
Propylene glycol is “generally recognized as safe” by the U.S. Food and Drug Administration (FDA) (FDA 2017). FDA considers an average daily dietary intake of 23 mg/kg of body weight to be safe for persons 2–65 years of age (ATSDR 2008). Various foods, cosmetics, and pharmaceutical products contain propylene glycol.
Is polyethylene glycol safe for kidneys?
Polyethylene glycol 3350 is a mixture of salts and polyethylene glycol that is commonly used in many over the counter laxatives. It is generally safe for patients with chronic kidney disease (CKD).
Is polyethylene glycol poisonous to humans?
A consequence of its low reactivity is that PEG does not exhibit toxicity in humans also because mammals do not have enzymes which are able to metabolize PEG. Therefore, once ingested or parenterally administered PEG remains intact until it is eliminated via urine or feces.