What is SERCA in muscle contraction?
What is SERCA in muscle contraction?
The sarcoendoplasmic reticulum (SR) calcium transport ATPase (SERCA) is a pump that transports calcium ions from the cytoplasm into the SR. Because the SERCA pump plays a major role in muscle contraction, a number of investigations have focused on understanding its role in cardiac and skeletal muscle disease.
What does SERCA do in skeletal muscle?
The sarco(endo)plasmic reticulum calcium ATPase (SERCA) is responsible for transporting calcium (Ca(2+)) from the cytosol into the lumen of the sarcoplasmic reticulum (SR) following muscular contraction. The Ca(2+) sequestering activity of SERCA facilitates muscular relaxation in both cardiac and skeletal muscle.
What does SERCA mean in English?
SERCA
| Acronym | Definition |
|---|---|
| SERCA | Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase |
| SERCA | Sarcoplasmic Reticulum (SR) Ca2+ ATPase (major regulator, Ca2+ homeostasis, contractility, cardiac & skeletal muscle) |
| SERCA | SE-R Club of America (automobile club) |
| SERCA | Software Engineering and Research Corporation of Australia |
Is SERCA in cardiac muscle?
Historically, SERCA is also known to be regulated by small transmembrane peptides, phospholamban (PLN) and sarcolipin (SLN). PLN is expressed in cardiac muscle, whereas SLN predominates in skeletal and atrial muscle.
Does SERCA cause relaxation?
A decreased expression and activity of SERCA pump could explain slowed rate of Ca2+ uptake and prolongation of muscle relaxation.
What type of transport is SERCA?
The sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) is an intracellular membrane transporter that utilizes the free energy provided by ATP hydrolysis for active transport of Ca2+ ions from the cytoplasm to the lumen of sarco(endo)plasmic reticulum.
Is SERCA present in smooth muscle?
Vascular smooth muscle cells (VSMC) express three isoforms of the sarcoplasmic or endoplasmic reticulum Ca2+-ATPase (SERCA) pump; SERCA2b predominates (91%), whereas SERCA2a (6%) and SERCA3 (3%) are present in much smaller amounts.
Why is SERCA important?
SERCA, or sarco/endoplasmic reticulum Ca2+-ATPase, or SR Ca2+-ATPase, is a calcium ATPase-type P-ATPase. Its major function is to transport calcium from the cytosol into the sarcoplasmic reticulum.
What cerca means?
cerca (superlative cerquísima) close, near, around, about, nearly, nigh (referring to quantity or time-related) close, near, around, nigh, at hand, close at hand, in sight (spatially) nearby, close by.
What type of transport is serca?
What is the purpose of the SERCA?
SERCA plays a fundamental role for cell calcium homeostasis and signaling in muscle cells and also in cells of other tissues. Because of its prominent role in many physiological processes, SERCA dysfunction is associated to diseases displaying various degrees of severity.
Why is the action of SERCA required for muscle relaxation?
The SERCA pumps catalyze Ca2+ transport across the membrane using the energy derived from ATP hydrolysis. SERCA2a exerts two main functions: decreases Ca2+ levels in the cytosol to initiate muscle relaxation and reload Ca2+ into SR, required for muscle contraction.