Which antibiotics are known to cause ototoxicity?

Ototoxic medications known to cause permanent damage include certain aminoglycoside antibiotics, such as gentamicin (family history may increase susceptibility), and cancer chemotherapy drugs, such as cisplatin and carboplatin.

Which aminoglycoside antibiotics causes more hearing loss?

In the treatment of severe infections, amikacin is mainly indicated on the basis of results of susceptibility tests and patient response. Tobramycin: Ototoxicity of tobramycin is similar to that of amikacin; high-frequency hearing loss results. As with kanamycin, vestibular toxicity is less common.

Which antibiotics are not ototoxic?

Kanamycin, also an aminoglycoside, was developed in 1957, and has been replaced by newer aminoglycosides such as gentamicin, tobramycin, netilmicin, and amikacin. It is not thought to be as ototoxic as neomycin.

How does streptomycin cause ototoxicity?

Aminoglycosides cause degeneration of sensory cells in the cochlea; usually involving the basal turn initially before progressing to the cochlea apex. This is the basis for the initial high frequency hearing loss subsequently followed by hearing loss in the lower frequencies.

Which drugs are ototoxic?

List of Ototoxic Medications

• Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), including aspirin, ibuprofen, and naproxen.
• Certain antibiotics, including aminoglycosides.
• Certain cancer medications.
• Water pills and diuretics.
• Quinine-based medications.

Does ototoxicity go away?

Ototoxicity can be temporary or permanent. The effect of certain drugs is often temporary, while other drugs typically produce permanent changes to the ear.

How is ototoxicity treated?

Aminoglycoside antibiotics, platinum-based chemotherapeutic agents, loop diuretics, macrolide antibiotics, and antimalarials are the commonly used ototoxic drugs [2] with well-documented efficacy against various infections and malignancies in children and adults.

Which antibiotic is most likely to cause damage to the ear?

The Problems with Certain Antibiotics Along with chemotherapy drugs, loop diuretics and nonsteroidal anti-inflammatory drugs (NSAIDs), aminoglycoside antibiotics such as gentamicin are one of the most ototoxic groups of drugs regularly prescribed. Their use can lead to temporary or permanent hearing loss and tinnitus.

How can ototoxicity be prevented?

If possible, avoid taking multiple types of ototoxic drugs (aspirin, quinine, loop diuretics, and aminoglycosides). When using airborne chemicals that are potentially ototoxic, good ventilation should be used. Open the windows, turn on a fan, and refrain from using the chemical for any longer than necessary.

Which medication has ototoxic side effects?

The American Tinnitus Association (ATA) recognizes that the following ototoxic drugs may cause more permanent tinnitus symptoms:

• Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), including aspirin, ibuprofen, and naproxen.
• Certain antibiotics, including aminoglycosides.
• Certain cancer medications.
• Water pills and diuretics.

How do I get rid of ototoxicity?

There is currently no cure for permanent ototoxicity; however, hearing aids can improve the effects of hearing loss and help people with ototoxicity live normal lives. If you have ototoxicity or want to learn more about your hearing aid options, visit TruHearing.com for more info.

What are signs and symptoms of ototoxicity?

What Are the Signs & Symptoms of Ototoxicity?

• no problems.
• minimal hearing loss but not notice a problem.
• “ringing in the ears” (tinnitus).
• major problems with balance.
• hearing problems, usually in both ears (called bilateral hearing loss).
• profound hearing loss (deafness)