Which vitamin deficiency can cause neonatal seizures?

B6 dependency syndromes are a group of metabolic disorders which respond to large doses of vitamin B6. Although rare, pyridoxine-dependent seizure (PDS) is a recognized cause of intractable seizures in neonates, psychomotor developmental delay, and, sometimes, death in untreated patients.

Why does pyridoxine deficiency cause seizures?

Vitamin B6 deficiency and seizures A deficiency of PLP leads to decreased GABA concentration in the brain, thereby increasing the risk for seizures (18). Seizures caused by vitamin B6 deficiency was first described in 1954 by Hunt et al (1).

Does pyridoxine cause anemia?

Low levels of pyridoxine can lead to numbness or tingling in the hands and feet (peripheral neuropathy) and seizures. This vitamin is needed for red blood cells to form. It’s needed for iron to convert into hemoglobin. Low levels of pyridoxine can cause anemia and many other health problems.

How is pyridoxine deficiency diagnosed?

Pyridoxine deficiency is diagnosed by measuring pyridoxine blood levels. Levels of 4-pyridoxic acid can be measured in the urine and are normally 128–680 nmol per nmol of creatinine. Urine levels of 4-pyridoxic acid are lower in women and are also reduced in persons with riboflavin deficiency (Attard et al., 2008).

What are the symptoms of low B6?

In adults, vitamin B6 deficiency can cause inflammation of the skin (dermatitis) and a red, greasy, scaly rash. The hands and feet may feel numb and prickling—like pins and needles. The tongue may become sore and red, and cracks may form in the corners of the mouth. People may become confused, irritable, and depressed.

What anemia is caused by vitamin B6 deficiency?

Vitamin B6 deficiency may present with seizures, mental status changes, normocytic anemia, a nonspecific pruritic rash, cheilitis, glossitis, and depression.

What are the symptoms of pyridoxine deficiency?

Symptoms and conditions associated with low pyridoxine levels

• General. Weakness. Dizziness.
• Cardiovascular. Atherosclerosis.
• Hematologic – Fatigue resulting from anemia is an example.
• Peripheral nervous system. Bilateral, distal limb numbness (appears early)
• Central nervous system (CNS) Depression.
• Gastrointestinal. Anorexia.

Is B6 good for anxiety?

Vitamin B6 has been used to treat symptoms of premenstrual syndrome, or PMS, including anxiety, depression and irritability. Researchers suspect that B6 helps with emotional symptoms related to PMS due to its role in creating neurotransmitters that regulate mood.

Can you take B6 at night?

How to use Melatonin 5 Mg-Pyridoxine (Vitamin B6) 1 Mg Tablet Vitamin B-6. This product is taken by mouth with or without food, usually before bedtime or as directed by the package label.

When does pyridoxine deficiency occur in Chinese women?

Pyridoxine Deficiency 1 Frequency. Idiopathic pyridoxine deficiency is very rare. 2 Race. Chinese women of childbearing age have an increased risk of developing pyridoxine deficiency. 3 Age. Hereditary sideroblastic anemia usually manifests within the first few years of life.

Are there any pyridoxine deficient patients with PDE?

The one clinical feature characteristic of all patients with PDE is intractable seizures that are not controlled with antiepileptic drugs but which do respond both clinically and usually on EEG (electroencephalographically) to large daily supplements of pyridoxine. These patients are not pyridoxine-deficient.

How is pyridoxine related to neonatal metabolic epilepsy?

Related Disorders. A closely related neonatal metabolic epilepsy is PNPO deficiency. Babies with this genetic disorder also have intractable seizures, but the seizures in these patients respond to pyridoxal-5’-phosphate (P5P, the biologically active form of pyridoxine) but in most instances do not respond to pyridoxine.

How is pyridoxine used to treat vitamin B6 deficiency?

Pyridoxine is a form of vitamin B6 used for the prophylaxis or treatment of vitamin B 6 deficiency resulting from conditions such as severe diarrhea, malabsorption, congenital metabolic dysfunction, hyperthyroidism, renal and hepatic disease, congestive heart failure, alcoholism, drug-induced conditions, and during pregnancy and lactation.