What are Pautrier Microabscesses?

Pautrier microabscesses: aggregates of atypical. CD4+ T-cells. within the. epidermis. that are indicative of the disease.

What is lymphocyte exocytosis?

My definition of exocytosis is the process of movement by lymphocytes from the blood vessels of the superficial dermis into the epithelium of the epidermis and/or epidermal appendages. [Exocytosis] represents a process. 7. Cytologically atypical lymphocytes within epidermis.

What is Sezary cells?

Listen to pronunciation. (sey-zah-REE sel) A cancerous T cell (a type of white blood cell) found in the blood, skin, and lymph nodes of patients who have a fast-growing type of skin lymphoma called Sézary syndrome.

What is mycosis fungoides?

Mycosis fungoides and Sézary syndrome are diseases in which lymphocytes (a type of white blood cell) become malignant (cancerous) and affect the skin. Mycosis fungoides and Sézary syndrome are types of cutaneous T-cell lymphoma. A sign of mycosis fungoides is a red rash on the skin.

What is Reticulosis?

Pagetoid reticulosis is a rare variant of mycosis fungoides that presents with a large, usually single, erythematous, slowly growing scaly plaque containing an intraepidermal proliferation of neoplastic T lymphocytes. Histopathologically, this disease has distinctive attributes.

What does Sezary Syndrome look like?

People with Sézary syndrome develop a red, severely itchy rash (erythroderma) that covers large portions of their body. Sézary cells are found in the rash. However, the skin cells themselves are not cancerous; the skin problems result when Sézary cells move from the blood into the skin.

What does Sézary syndrome feel like?

Are Sezary cells T cells?

Sézary disease and mycosis fungoides are cutaneous T-cell lymphomas having a primary manifestation in the skin.

How serious is mycosis fungoides?

Open sores may develop on the tumors, often leading to infection. Although rare, the cancerous T cells can spread to other organs, including the lymph nodes, spleen, liver, and lungs. Spread to other organs can occur in any stage of mycosis fungoides but is most common in the tumor stage.

What is the life expectancy of someone with mycosis fungoides?

Patients with stage IA-disease have an excellent prognosis with an overall long-term life expectancy that is similar to an age-, sex-, and race-matched control population. Almost all patients with stage IA MF will die from causes other than MF, with a median survival >33 years.