What does it mean when you have immature platelet fraction?

Another test, the immature platelet fraction (IPF) reflects the amount of young, reticulated platelets. IPF is calculated by automated hematology analysis or flow cytometry, and it is usually high in patients with rapid platelet destruction. For both MPV and IPF, standardization of cutoff is a major need.

What does a high IPF mean?

Together with a low platelet count, an increased IPF indicates an increase in platelet production. This is seen in patients with excessive destruction of platelets. An example of the clinical utility of the IPF can be seen in the diagnosis of immune thrombocytopenic purpura (ITP).

What diseases cause low MPV?

Conditions that may be associated with a low MPV and variable platelet counts include:

• Bone marrow failure.
• Lupus.
• Splenomegaly (an enlargement of the spleen), which often causes platelets to be trapped in the spleen.
• Medications that suppress platelet formation, such as chemotherapy.
• Hypothyroidism.
• Iron deficiency anemia.

What are immature platelets called?

IPF is the percentage of immature platelets (also called reticulated platelets) circulating in the blood.

What happens when platelet count increases?

A high platelet count can cause blood clots to develop spontaneously. Normally, your blood begins to clot to prevent a massive loss of blood after an injury. In people with primary thrombocythemia, however, blood clots can form suddenly and for no apparent reason. Abnormal blood clotting can be dangerous.

Is IPF a death sentence?

Idiopathic Pulmonary Fibrosis (IPF) is a rare, progressive lung disease. While there are not formal categories of IPF, doctors and patients sometimes think of IPF in four different stages depending on symptoms and treatment needs. IPF can be a scary diagnosis, but it’s not a death sentence.

What does it mean when your MPV count is low?

A low MPV can indicate exposure to certain drugs that are harmful to cells. It may also indicate marrow hypoplasia, a disorder that causes a decrease in blood cell production.

How are platelet volume and immature platelet fraction measured?

Size correlates with cell activity and can be assessed by volume indices ( 4 ). Among them, the mean platelet volume (MPV), routinely measured in blood cell count, and the immature platelet fraction (IPF) are tests of current interest ( 5 ).

What is the role of immature platelets in ACS?

Platelets have a central role in the pathogenesis of ACS. Immature Platelet Fraction (IPF) considered as a potential marker of the platelet activation process and platelet turnover process.

What’s the difference between platelet fraction and IPF?

The IPF showed the highest difference between the two patient groups (200%). Receiver operating characteristics analysis that showed the IPF had the largest area under the curve among all the platelet indices analyzed; its cut-off value was 2.3%.

What does a low platelet count mean for MPV?

Viral Infection – A low platelet count indicates that you are suffering from viral infection such as Dengue fever and AIDS. (5) Side effects of medications – Some drugs lowers MPV such as heparin. Genetic disorder/autoimmune disorder – Patients suffering from genetic conditions have low mean platelet volume.