What does pyrazinamide target?

What does pyrazinamide target?

Pyrazinamide kills or stops the growth of certain bacteria that cause tuberculosis (TB). It is used with other drugs to treat tuberculosis. It is a highly specific agent and is active only against Mycobacterium tuberculosis.

What is the Mycobacterium tuberculosis drug target for pyrazinamide?

It is likely that PanD is a target of PZA and that POA binding to PanD could inhibit pantothenate and co-enzyme A biosynthesis, which is critical for central metabolism required for energy production and fatty acid metabolism in M. tuberculosis.

What bacteria is sensitive to pyrazinamide?

tuberculosis is uniquely susceptible to pyrazinamide, and this unique pyrazinamide susceptibility correlates with a deficient pyrazinoic acid efflux mechanism in this organism, whereas the naturally pyrazinamide-resistant Mycobacterium smegmatis has a highly active pyrazinoic acid efflux mechanism that quickly extrudes …

What is the cellular target of isoniazid?

The primary target of isoniazid is believed to be InhA, a NADH-dependent enoyl acyl carrier protein reductase involved in the synthesis of mycolic acid. The activated species, presumably an isonicotinic acyl radical, forms an adduct with the NAD radical.

What drugs interact with pyrazinamide?

View interaction reports for pyrazinamide and the medicines listed below.

  • Acetylsalicylic Acid (aspirin)
  • Atrovent (ipratropium)
  • Augmentin (amoxicillin / clavulanate)
  • Baraclude (entecavir)
  • Bisolvon Dry (dextromethorphan)
  • Chlorpheniramine (Allergy) (chlorpheniramine)
  • Kalydeco (ivacaftor)

What are the side effects of pyrazinamide?

What are the possible side effects of pyrazinamide?

  • fever;
  • joint pain or swelling;
  • easy bruising or bleeding (nosebleeds, bleeding gums);
  • gout flare-up symptoms –joint pain, stiffness, redness, or swelling (especially at night); or.

What is pyrazinamide used for?

Pyrazinamide kills or stops the growth of certain bacteria that cause tuberculosis (TB). It is used with other drugs to treat tuberculosis. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

What are second line drugs?

Second line drugs are the TB drugs that are used for the treatment of drug resistant TB. The second line drugs include levofloxacin, moxifloxacin, bedaquiline, delamanid and linezolid. There is also pretomanid which is a new second line drug recommended in 2019 for the treatment of drug resistant TB.

Why is B6 given with isoniazid?

Vitamin B6 (pyridoxine) supplementation during isoniazid (INH) therapy is necessary in some patients to prevent the development of peripheral neuropathy.

What is the side effect of pyrazinamide?

Nausea, vomiting, loss of appetite, or mild muscle/joint pain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Why is multiple drugs used to treat TB?

When two or more drugs to which in vitro susceptibility has been demonstrated are given together, each helps prevent the emergence of tubercle bacilli resistant to the others. The standard of care for initiating treatment of TB disease is four-drug therapy.