What is NMP22 test?

The Alere NMP22® Test Kit is an enzyme immunoassay (EIA) for the in vitro quantitative determination of the nuclear mitotic apparatus protein (NuMA) in stabilized voided urine. NuMA is an abundant component of the nuclear matrix proteins (NMP22).

What is a Urovysion fish test?

Urovysion™ fluorescence in situ hybridization (FISH) is a sensitive and specific test used to diagnose urothelial carcinoma in urine. It detects aneuploidy of chromosomes 3, 7 and 17, and loss of both 9p21 loci in malignant urothelial cells.

What is cytology urine test for?

Urine cytology: In this test, a microscope is used to look for cancer cells in urine. Urine cytology does find some cancers, but it’s not reliable enough to make a good screening test. Urine tests for tumor markers: Newer tests look for certain substances in urine that might be a sign of bladder cancer.

How accurate is a urine cytology test?

Urine cytology is associated with a significant false-negative rate, especially for low-grade carcinoma (10-50% accuracy rate). The false-positive rate is 1-12%, although cytology has a 95% accuracy rate for diagnosing high-grade carcinoma and CIS. Urine cytology is often the test used for diagnosis of CIS.

Can a urine test detect liver problems?

A urinalysis is a simple test that looks at a small sample of your urine. It can help find problems that need treatment, including infections or kidney problems. It can also help find serious diseases in the early stages, like kidney disease, diabetes, or liver disease. A urinalysis is also called a “urine test.”

What tests will urologist do for blood in urine?

Often, an imaging test is required to find the cause of hematuria. Your doctor might recommend a CT or MRI scan or an ultrasound exam. Cystoscopy. Your doctor threads a narrow tube fitted with a tiny camera into your bladder to examine the bladder and urethra for signs of disease.

How does the NMP22 test for bladder cancer work?

The NMP22® BladderChek® Test is a painless, noninvasive assay performed on a single urine sample that provides results during a patient visit. It works by detecting levels of NMP22® protein, which are often elevated in patients with bladder cancer,

What is the sensitivity of the NMP22 test?

The sensitivity of NMP22 test is recorded to be 81.3% which is significantly greater than urine cytology which has a sensitivity of 44%. Thus, NMP22 is another wonder of science contributing majorly towards diagnostic tests for bladder cancers. A single void of urine is collected at any time between midnight and noon.

What is the reference cut off for NMP22?

This test is a quantitative enzyme immunoassay which utilizes two monoclonal antibodies (mAb302-18, mAb 302-22). The manufacturer recommends a reference cut-off level of 10 U/mL but lower cut-off levels have been used with higher degree of accuracy.

How long does it take for NMP 22 results?

NMP 22 is a method of cancer detection approved by the FDA and CE. It is known as “NMP 22 bladder check” on commercial grounds. The process is convenient and quick because results can be obtained within the first 30 minutes of the test.