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What is the mechanism of action of abiraterone?

What is the mechanism of action of abiraterone?

Mechanism of Action Abiraterone acetate is converted in vivo to abiraterone, an androgen biosynthesis inhibitor, that inhibits 17 a-hydroxylase/C17,20-lyase (CYP17). This enzyme is expressed in testicular, adrenal, and prostatic tumor tissues and is required for androgen biosynthesis.

Why does abiraterone need to be given with prednisone?

Abiraterone is used in combination with the steroid prednisone to help minimize the risk of hypertension, Fizazi said.

Is abiraterone an androgen receptor inhibitor?

In contrast to canonical antiandrogens which target androgen receptor, abiraterone acetate is an androgen biosynthesis inhibitor, and the only one approved by the FDA for use in PC at this time (Figure 1 and Table 1) As such, it targets cytochrome P450 enzyme 17R-hydroxylase-17,20-lyase (CYP17).

What does abiraterone acetate do?

ZYTIGA® (abiraterone acetate) is a prescription medicine that is used along with prednisone. ZYTIGA® is used to treat men with prostate cancer that has spread to other parts of the body.

What is the cost of abiraterone?

About Abiraterone ABIRATERONE blocks the effect of the male hormone called testosterone. This medicine is used for certain types of prostate cancer. The lowest GoodRx price for the most common version of abiraterone is around $237.60, 96% off the average retail price of $6,712.00.

Is abiraterone a hormone?

What is abiraterone? Abiraterone acetate (Zytiga®) is a type of hormone therapy for men with prostate cancer that has spread to other parts of the body (advanced prostate cancer).

How long can you live on abiraterone?

Life expectancy: The studies show that abiraterone acetate can prolong life. In the larger study, about 50 out of 100 men who had the standard treatment were still alive after 3 years, while after the same period of time 70 out of 100 men who had treatment with abiraterone acetate were still alive.

How effective is abiraterone?

During abiraterone plus prednisone treatment, 65% of patients had a ⩾50% prostate-specific antigen decline, and quality of life remained appreciably high. Among symptomatic patients according to the Brief Pain Inventory) (32%), scores significantly declined after 6 months of treatment.

How do androgen receptor inhibitors work?

Androgen receptor inhibitors are used to slow down or stop the growth of cancer cells to treat prostate cancer. They work by inhibiting androgen hormones.

What is anti-androgen medication?

Anti-androgens are medications that block the effects of androgens in the body. Finasteride is an anti-androgen that affects the levels of two androgens – testosterone and dihydrotestosterone (DHT).

How effective is abiraterone acetate?

The pooled analysis reported abiraterone acetate showed significant efficacy in high-risk prostate cancer patients, including overall survival (OS) [HR 0.66, 95% confidence interval (CI), 0.61–0.73, P<0.001], the time to prostate-specific antigen (PSA) progression (HR 0.45, 95% CI, 0.34–0.59, P<0.001), progression-free …

Does abiraterone affect the immune system?

Abiraterone doesn’t affect your immune system or involve regular hospital visits. For this reason, abiraterone may be safer for you than chemotherapy until the risk from coronavirus in the UK has reduced.

Are there any phase 3 trials for abiraterone?

Full details of the COU-AA-301 study are provided in the initial report. Abiraterone and increased survival in metastatic prostate cancer. Briefly, in this phase 3, multinational, double-blind, randomised placebo-controlled trial, we enrolled patients from 147 sites in 13 countries.

What is the effect of abiraterone acetate on testosterone?

Abiraterone acetate, via abiraterone, has the capacity to lower circulating testosterone levels to less than 1 ng/dL (i.e., undetectable) when added to castration. These concentrations are considerably lower than those achieved by castration alone (~20 ng/dL).

How many patients are treated with abiraterone acetate plus prednisone?

This study is registered with, number NCT00638690. Of the 1195 eligible patients, 797 were randomly assigned to receive abiraterone acetate plus prednisone (abiraterone group) and 398 to receive placebo plus prednisone (placebo group).

What is the developmental code name for abiraterone acetate?

Abiraterone acetate is the generic name of the drug and its USAN, BANM, and JAN, while abiraterone is the INN and BAN of abiraterone, its deacetylated form. Abiraterone acetate is also known by its developmental code names CB-7630 and JNJ-212082, while CB-7598 was the developmental code name of abiraterone.