What is ticlid used for?
What is ticlid used for?
Ticlopidine is used to reduce the risk of stroke in people who have had a stroke or have had warning signs of a stroke and who cannot be treated with aspirin.
What is the mechanism of action of ticlopidine?
Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation.
Why was ticlid discontinued?
Ticlopidine was approved for use in the United States in 1991, but it is currently rarely used, largely because of the risks of serious side effects including agranulocytosis, thrombotic thrombocytopenic purpura and aplastic anemia and the availability of clopidogrel, which has a similar mechanism of action and …
What are side effects of ticlopidine?
Common side effects of Ticlid include:
- stomach upset or pain,
- ringing in your ears, or.
When should I take Ticlid?
How to use Ticlopidine 250 Mg Tablet
- Read the Patient Information Leaflet if available from your pharmacist before you start taking ticlopidine and each time you get a refill.
- Take this medication by mouth with food or just after a meal as directed by your doctor, usually twice daily.
What is the mechanism of action of dipyridamole?
Dipyridamole appears to act in vivo by synergistically modifying several biochemical pathways, including: a) inhibition of platelet cAMP-phosphodiesterase; b) potentiation of adenosine inhibition of platelet function by blocking reuptake by vascular and blood cells, and subsequent degradation of adenosine; and possibly …
Which drugs are related to ticlopidine?
Interactions. Ticlopidine interacts with several classes of medications. It increases the antiplatelet effects of aspirin and other NSAIDs. Taking ticlopidine at the same time as antacids decreases the absorption of ticlopidine.
Is ticlid a blood thinner?
Ticlopidine is an oral drug that inhibits the ability of platelets to clump and form blood clots. It prevents blood clots by binding to the P2Y12 receptor on platelets, preventing adenosine diphosphate (ADP) from activating platelets. It belongs to a class of drugs called P2Y12 inhibitors.
Is aspirin a ticlopidine?
Stroke. Ticlopidine is considered a second-line option for the prevention of thrombotic strokes among patients who have previously had a stroke or TIA. Studies have shown that it is superior to aspirin in the prevention of death or future strokes.
What is the antidote for ticlopidine?
Platelet transfusions may also be used to reverse the effect of TICLID (ticlopidine hcl) on bleeding. Because platelet transfusions may accelerate thrombosis in patients with TTP on ticlopidine, they should, if possible, be avoided.
What is the antidote for dipyridamole?
Dipyridamole overdose can be treated with aminophylline or caffeine which reverses its dilating effect on the blood vessels.
Is dipyridamole a vasodilator?
Dipyridamole is a pyramidopyrimidine compound that, acting as a phosphodiesterase inhibitor, modestly reduces platelet function. Dipyridamole also has important endothelial activity and acts as a vasodilator. Dipyridamole inhibits the attachment of platelets to the endothelium.
Mechanism of action Ticlopidine is a thienopyridine which, when metabolized by the body, irreversibly blocks the P2Y12 component of the ADP receptor on the surface of platelets. Without ADP, fibrinogen does not bind to the platelet surface, preventing platelets from sticking to each other.
What kind of platelet aggregation inhibitor is Ticlid?
TICLID (ticlopidine hydrochloride) is a platelet aggregation inhibitor. Chemically it is 5-[(2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno [3,2-c] pyridine hydrochloride.
What is the chemical formula for Ticlid hydrochloride?
Ticlid (ticlopidine hydrochloride) is a platelet aggregation inhibitor. Chemically it is 5- [ (2-chlorophenyl)methyl]-4,5,6,7-tetrahydrothieno [3,2-c] pyridine hydrochloride. The structural formula is: Ticlopidine hydrochloride is a white crystalline solid.
When do side effects of Ticlid start to occur?
Severe hematological adverse reactions may occur within a few days of the start of therapy. The incidence of TTP peaks after about 3 to 4 weeks of therapy and neutropenia peaks at approximately 4 to 6 weeks. The incidence of aplastic anemia peaks after about 4 to 8 weeks of therapy.