Why is Zofran contraindicated in prolonged QT?

The drug may increase the risk of prolongation of the QT interval of the electrocardiogram, which can lead to abnormal and potentially fatal arrhythmias, including torsade de pointes, according to an FDA press release.

How much does Zofran prolong QT?

Of the 22 patients included in the final analysis, ondansetron administration was associated with an increase in the QT interval by 20 ms (95% CI, 14.0 mg to 26 mg; p<0.0001). A pairwise analysis similarly demonstrated a significant prolongation of the QT interval at 6, 12, and 14 minutes.

Does oral Zofran prolong QTc?

– ECG changes including QT interval prolongation have been seen in patients receiving Zofran (ondansetron). In addition, Torsade de Pointes, an abnormal heart rhythm, has been reported in some patients receiving ondansetron.

What does Zofran do to QTc?

Results: Among patients included in the data analysis (n = 20), ondansetron administration was associated with a mean QTc increase of 16.2 msec (95% confidence interval, 4.2-28.2 msec; p = 0.01) and a median increase of 12 msec (interquartile range, 5.5-18.0 msec; p < 0.01).

Can you take Zofran with long QT syndrome?

The label of the anti-nausea drug Zofran (ondansetron, ondansetron hydrochloride and generics) is being updated to include a warning to avoid use in patients with congenital long QT syndrome because of increased risk of developing a potentially fatal heart rhythm, including Torsade de Pointes, according to the Food and …

What QTc to avoid with Zofran?

The use of a single 32 mg intravenous dose of ondansetron should be avoided. New information indicates that QT prolongation occurs in a dose-dependent manner, and specifically at a single intravenous dose of 32 mg.

When should you hold Zofran?

To prevent nausea from radiation treatment, take this medication by mouth 1 to 2 hours before the start of your treatment. To prevent nausea after surgery, take ondansetron by mouth 1 hour before the start of surgery. This medication may be taken with or without food.

CAN expired Zofran hurt you?

Do not take Ondansetron SZ ODT orally disintegrating tablets after the expiry date (EXP) printed on the pack. If you take it after the expiry date has passed, it may not work as well.