What is the inhibitor of maltase?

Acarbose or maltose was used to inhibit maltase-glucoamylase, an enzyme present in polymorphonuclear neutrophils that contributes to the total α-glucosidase activity at acidic pH. By using 4 mM maltose as the inhibitor, heterozygotes and patients were not completely separated.

Is maltase an alpha-glucosidase?

This enzyme catalyzes the hydrolysis of disaccharide maltose into two simple sugars of glucose. Maltase is found in plants, bacteria, yeast, humans, and other vertebrates. The activities of these four maltases are also described as alpha-glucosidase because they all digest linear starch oligosaccharides to glucose.

Is maltose A inhibitor?

This result accords with results described in the literature in which maltose was shown to be a competitive inhibitor of amylase action.

What drugs are alpha glucosidase inhibitors?

Alpha-glucosidase inhibitors (AGIs; acarbose, miglitol, voglibose) are widely used in the treatment of patients with type 2 diabetes. AGIs delay the absorption of carbohydrates from the small intestine and thus have a lowering effect on postprandial blood glucose and insulin levels.

What type of inhibitor is sucrose?

The inhibition of the sugar-cane enzyme by sucrose was shown to be partially competitive. The K(i) for sucrose is about 10mm. 4. Melezitose is also a partially competitive inhibitor of the enzyme but the inhibition by maltose is probably mixed.

What is the difference between alpha and beta glucosidase?

α-Glucosidase (EC 3.2. 1.20) is an enzyme that catalyses the hy- drolysis of 1,4-α-glucosidic linkages, releasing α-glucose. β-Glucosidase hydrolyses β 1–4 linkages between two glucoses or glucose-substituted mol- ecules (such as cellobiose) (Terra et al. 1996).

What is the end product of maltose?

Maltose and isomaltose are the disaccharides (glucose-glucose) produced as end products of starch digestion….2 Disaccharide Digestion.

What are the side effects of alpha-glucosidase inhibitors?

α-Glucosidase inhibitors are associated with significant gastrointestinal side effects that affect over 50% of individuals. Increased colonic gas production due to fermentation of unabsorbed carbohydrate cause abdominal bloating, cramping, increased flatulence, or diarrhea.

How effective are alpha-glucosidase inhibitors?

An alpha-glucosidase inhibitor will usually lower your A1c (the “average” of your blood sugar control over a few months) by about 0.5% to 0.8%.

Is maltose better than sugar?

Maltose is a sugar that tastes less sweet than table sugar. It contains no fructose and is used as a substitute for high-fructose corn syrup. Like any sugar, maltose may be harmful if consumed in excess, leading to obesity, diabetes and heart disease ( 3 ).

How is maltose used to inhibit maltase glucoamylase?

Acarbose or maltose was used to inhibit maltase-glucoamylase, an enzyme present in polymorphonuclear neutrophils that contributes to the total α-glucosidase activity at acidic pH.

How does acarbose inhibit alpha glucosidase in diabetes?

Diabetes: Acarbose, an alpha-glucosidase inhibitor, competitively and reversibly inhibits alpha-glucosidase in the intestines. This inhibition lowers the rate of glucose absorption through delayed carbohydrate digestion and extended digestion time.

Can a small intestinal alpha glucosidase be inhibited?

Yeast and rat small intestinal alpha-glucosidases have been shown to be inhibited by several groups of flavonoids. Alpha-glucosidases can be divided, according to primary structure, into two families.

What was the purpose of the maltose and acarbose study?

Purpose: The study’s purpose was to compare acarbose and maltose as inhibitors of maltase-glucoamylase activity for determining acid α-glucosidase activity in dried blood spot specimens for early identification of patients with infantile Pompe disease, a severe form of acid α-glucosidase deficiency.